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Lensless Fluorescent Microscopy on a Chip
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Compact Lensless Fluorescence Counting System for Single Molecular Assay.

Hironari Takehara, Yuta Nakamoto, Narihito Ikeda

    IEEE Transactions on Biomedical Circuits and Systems
    |July 12, 2018
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    Summary

    We developed a compact system for counting fluorescent chambers in digital enzyme-linked immunosorbent assays. This system enables sensitive biomarker detection by identifying single molecular enzyme fluorescence within 30 minutes.

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    Area of Science:

    • Biomedical Engineering
    • Analytical Chemistry
    • Optoelectronics

    Background:

    • Digital enzyme-linked immunosorbent assay (ELISA) relies on counting fluorescent chambers for biomarker quantification.
    • Accurate counting is crucial for reliable biomarker detection and diagnosis.

    Purpose of the Study:

    • To propose and describe a novel compact system for efficient fluorescent chamber counting in digital ELISA.
    • To enhance sensitivity and reduce detection time for biomarker analysis.

    Main Methods:

    • A system comprising a micro-reaction chamber array, a micro-light-pipe array (m-LPA) absorption filter, and a color-discriminating CMOS image sensor (CIS) photodetector.
    • Fabrication of thin m-LPA chips and utilization of a stacked photodiode CIS with 4T-APS configuration for low-noise, high-sensitivity detection.
    • Implementation of a photobleaching-based detection method for enhanced fluorescence signal analysis.

    Main Results:

    • The developed system enables sensitive detection of fluorescence from single molecular enzymes.
    • High sensitivity is achieved through the low-noise characteristics of the stacked photodiode CIS.
    • The proposed method allows for fluorescence detection within 30 minutes of reaction initiation.

    Conclusions:

    • The compact system offers a promising solution for high-sensitivity biomarker detection in digital ELISA.
    • The integration of m-LPA and advanced CIS technology significantly improves fluorescence quantification.
    • The photobleaching detection method accelerates the diagnostic process by enabling rapid single-molecule detection.