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Published on: January 3, 2017
Assessment of serotonergic system in formation of memory and learning
J C da Silva1, C A M Amorim1, G P Rodrigues1
1Laboratório de Neurociência e Comportamento, Núcleo de Ciências Biológicas - NUCIB, Universidade Estadual de Ciências da Saúde de Alagoas - UNCISAL, Rua Doutor Jorge de Lima, 113, Trapiche da Barra, CEP 57010-382, Maceió, AL, Brazil.
Abstract:
We evaluated the involvement of the serotonergic system on memory formation and learning processes in healthy adults Wistar rats. Fifty-seven rats of 5 groups had one serotonergic nuclei damaged by an electric current. Electrolytic lesion was carried out using a continuous current of 2mA during two seconds by stereotactic surgery. Animals were submitted to learning and memory tests. Rats presented different responses in the memory tests depending on the serotonergic nucleus involved. Both explicit and implicit memory may be affected after lesion although some groups showed significant difference and others did not. A damage in the serotonergic nucleus was able to cause impairment in the memory of Wistar. The formation of implicit and explicit memory is impaired after injury in some serotonergic nuclei.
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