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Admission Serum Calcium Level as a Prognostic Marker for Intracerebral Hemorrhage

Li Tu1, Xiujuan Liu2, Tian Li2,3

  • 1Department of General Medical, the Affiliated Hospital of Guizhou Medical University, Guiyang, People's Republic of China.

Neurocritical Care
|July 12, 2018
PubMed

Insights

Low admission serum calcium levels in patients with intracerebral hemorrhage are linked to a higher risk of poor prognosis, including death or major disability. This finding suggests serum calcium may serve as a prognostic marker.

Area of Science:

  • Neurology
  • Biochemistry

Background:

  • The prognostic significance of serum calcium levels in patients with intracerebral hemorrhage (ICH) is not well-established.
  • ICH is a critical neurological condition with significant mortality and morbidity.

Purpose of the Study:

  • To investigate the relationship between admission serum calcium levels and the 90-day prognosis in patients diagnosed with ICH.
  • To determine if serum calcium can serve as a predictive biomarker for ICH outcomes.

Main Methods:

  • A cohort of 1262 patients with confirmed ICH was analyzed.
  • Data collected included demographics, medical history, laboratory results (serum calcium, INR, APTT), imaging (hematoma volume), and clinical scores.
  • Ninety-day prognosis was assessed, with poor outcome defined as death or major disability.

Main Results:

  • Patients with poor prognosis had significantly lower admission serum calcium levels (2.41 ± 0.23 mmol/l) compared to those with good prognosis (2.55 ± 0.26 mmol/l).
  • Higher INR and hematoma volume were also associated with poor prognosis.
  • Multivariate COX regression revealed that serum calcium ≤ 2.41 mmol/l increased the risk of poor prognosis (HR 1.45).
  • Serum calcium showed a significant inverse linear association with coagulation markers (APTT, INR) and hematoma volume.

Conclusions:

  • Admission serum calcium level may function as a valuable prognostic marker for intracerebral hemorrhage.
  • The observed association suggests a potential role of calcium in calcium-induced coagulation abnormalities impacting ICH outcomes.
Abstract

Keywords:
CalciumCoagulation functionHematoma expansionHematoma volumeIntracerebral hemorrhage

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