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MIF-173G/C (rs755622) polymorphism as a risk factor for acute lymphoblastic leukemia development in children

Mohamed Sharaf-Eldein1, Doaa Elghannam2, Camelia Abdel-Malak1

  • 1Department of Biochemistry, Faculty of Sciences, Damietta University, New Damietta, Egypt.

The Journal of Gene Medicine
|July 12, 2018
PubMed
Abstract

Insights

The MIF-173G/C polymorphism is a risk factor for childhood acute lymphoblastic leukemia (ALL) in Egyptian children. The CC genotype and increased C-allele representation are linked to higher white blood cell counts, suggesting a poorer prognosis.

Area of Science:

  • Genetics and Molecular Biology
  • Immunology
  • Pediatric Oncology

Background:

  • Macrophage inhibitory factor (MIF) is a pro-inflammatory cytokine involved in various biological processes.
  • The MIF-173G/C (rs755622) polymorphism in the promoter region influences MIF gene activity.
  • This polymorphism has been investigated for its potential role in disease development.

Purpose of the Study:

  • To investigate the MIF-173G/C (rs755622) polymorphism as a risk factor for acute lymphoblastic leukemia (ALL) in Egyptian children.
  • To assess the association between MIF genotypes and ALL development.
  • To explore the prognostic implications of the MIF polymorphism in childhood ALL.

Main Methods:

  • Genotyping of the MIF-173G/C (rs755622) polymorphism using polymerase chain reaction (PCR) and restriction endonuclease digestion.
  • Analysis of 180 Egyptian children with ALL and 150 healthy controls.
  • Agarose gel electrophoresis for product visualization.

Main Results:

  • A significant association was found between the homozygous polymorphic (CC) genotype and combined polymorphic genotypes (GC + CC) of MIF-173G/C and ALL development.
  • The wild-type (GG) genotype was more prevalent in healthy controls.
  • Multivariate analysis identified the CC genotype as a significant risk factor for ALL (p=0.02).
  • Increased C-allele representation correlated with higher total leukocytic counts, suggesting a potential negative prognostic impact.

Conclusions:

  • The MIF-173G/C (rs755622) polymorphism, particularly the CC genotype and combined polymorphic genotypes, is a risk factor for childhood ALL in the Egyptian population.
  • The association of the polymorphic C-allele with increased leukocytic count may indicate a poorer prognosis in childhood ALL.
  • Further research is warranted to confirm the prognostic significance of this polymorphism.
Keywords:
acute lymphoblastic leukemiamacrophage inhibitory factorpolymorphism

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