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Elevated Vitamin B12: A Rare Presentation for Gallbladder Adenocarcinoma
Khalil Aloreidi1, Alla Zamulko1
1Department of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
Summary
Elevated Vitamin B12 (Cobalamin) levels can indicate underlying cancer. This case highlights how high Cobalamin prompted diagnosis of gallbladder adenocarcinoma, improving patient outcomes.
Area of Science:
- Oncology
- Clinical Biochemistry
Background:
- Gallbladder cancer (GBC) presents insidiously, often diagnosed late.
- Vitamin B12 (Cobalamin [Cbl]) deficiency is common, but elevated Cbl is under-recognized.
Observation:
- An elderly patient presented with generalized weakness.
- Serum Cbl levels were found to be elevated, raising suspicion for malignancy.
Findings:
- Further investigations, including imaging and biopsy, confirmed gallbladder adenocarcinoma.
- Elevated Cbl is linked to increased cancer risk and poorer prognosis in cancer patients.
Implications:
- Incidental high Cbl levels can serve as an early warning for occult malignancies.
- Prompt diagnosis of GBC, aided by elevated Cbl, can lead to earlier intervention and potentially better outcomes.
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