[EV71 Infection and Innate Antiviral Innate Immunity]

Enterovirus 71 (EV71) is a major agent of hand, foot, and mouth disease in children under five years of age. In some cases,infection with EV71 can result in herpangina, pulmonary edema and/or brainstem encephalitis. In recent years, many advances have been made towards an understanding of EV71 pathogenesis. In this review, we summarize the cell types targeted by EV71,the activation of signaling pathways, the innate antiviral immune response and immune evasion by EV71 to better understand the immunopathogenesis of EV71 and to aid in the development of antiviral drugs.