Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Replication02:40

DNA Replication

59.6K
DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication...
59.6K
The DNA Replication Fork01:02

The DNA Replication Fork

41.1K
An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication...
41.1K
The DNA Replication Fork01:02

The DNA Replication Fork

18.5K
18.5K
Recombinant DNA01:09

Recombinant DNA

103.4K
Overview
103.4K
S-Cdk Initiates DNA Replication02:38

S-Cdk Initiates DNA Replication

5.7K
The cell cycle is a series of events leading to DNA duplication followed by the division of cell content to form two daughter cells. The cell cycle progresses in four stages—the cell increases in size (gap 1 or G1-phase), duplicates its DNA (synthesis or S-phase), prepares to divide (gap 2 or G2-phase), and divides (mitosis or M-phase).
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of...
5.7K
Translesion DNA Polymerases02:10

Translesion DNA Polymerases

11.2K
Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
TLS polymerases are found in all three domains of life - archaea, bacteria, and eukaryotes. Of the different classes of TLS polymerases, members of the Y family are fitted with specialized structures that...
11.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A conserved mechanism for stabilization of viral innate immune antagonists via interaction with Elongin BC.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS).

Communications biology·2026
Same author

Differential assembly of RNP granules via activation of distinct dsRNA sensors by adenovirus mutants.

bioRxiv : the preprint server for biology·2026
Same author

FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments.

Science (New York, N.Y.)·2025
Same author

Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress.

Molecular cell·2025
Same author

Probing condensate microenvironments with a micropeptide killswitch.

Nature·2025

Related Experiment Video

Updated: Feb 7, 2026

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration
08:41

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration

Published on: December 27, 2024

2.0K

Virus DNA Replication and the Host DNA Damage Response.

Matthew D Weitzman1,2, Amélie Fradet-Turcotte3,4

  • 1Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

Annual Review of Virology
|July 12, 2018
PubMed
Summary

DNA viruses manipulate host DNA repair pathways for replication. Understanding these viral hijacking strategies is crucial for insights into viral replication and host genome stability.

Keywords:
DNA damage responsechromatin stateviral genomevirus replicationvirus replication compartments

More Related Videos

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
10:24

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins

Published on: September 28, 2012

14.6K
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

11.5K

Related Experiment Videos

Last Updated: Feb 7, 2026

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration
08:41

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration

Published on: December 27, 2024

2.0K
Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
10:24

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins

Published on: September 28, 2012

14.6K
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

11.5K

Area of Science:

  • Molecular Biology
  • Virology
  • Genetics

Background:

  • Viral DNA genomes possess limited coding capacity, necessitating the use of host cellular factors for replication.
  • Interactions between viruses and cellular processes offer fundamental insights into biology and disease.

Purpose of the Study:

  • To highlight the consequences of virus-host interactions on viral replication.
  • To examine the impact on host genome integrity during DNA virus replication.

Main Methods:

  • Review of existing literature on DNA virus replication strategies.
  • Analysis of how viruses engage and manipulate host DNA damage and repair machinery.

Main Results:

  • DNA viruses engage host DNA damage and repair machinery for their life cycles.
  • Viruses employ diverse strategies to navigate and exploit the cellular DNA damage response.
  • Hijacking these cellular processes can lead to selective harnessing or abrogation of specific repair components.

Conclusions:

  • Viral manipulation of host DNA repair impacts both viral replication efficiency and host genome integrity.
  • Understanding these dynamic interactions is key to deciphering viral pathogenesis and host responses.