Related Experiment Video
Updated: Feb 7, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
Increasing the Sensitivity of Functional Status Assessment in the Preclinical Range (Normal to Mild Cognitive
1Center for Cognitive Aging and Memory, Department of Geriatric Research, College of Medicine, University of Florida, Gainesville, Florida, USA.
Background/Aims:
Dementia exhibits an insidious onset consisting of cognitive, behavioral, and functional impairment. We explored a functional continuum that extends assessment beyond the clinical instrumental activities of daily living (IADL) range and into advanced activities of daily living.
Methods:
We examined the predictive power (Cox regression; n = 2,471) of a unidimensional IADL-extended (IADL-x) scale for incident mild cognitive impairment (MCI). We also examined "time to MCI" as an outcome measure.
Results:
Each additional task endorsed on the IADL-x hierarchy (e.g., endorsing participation in 6 vs. 5 activities) resulted in a 10% reduction in MCI risk (HR 0.90, 95% CI 0.85-0.94, p < 0.001). For the fully adjusted model the risk reduction dropped to 6%. The odds of incident MCI within 2 years (for those below the median IADL-x total score) was 2.5 times higher (OR 2.60, 95% CI 1.52-4.4, p < 0.001) and 2 times higher for incident MCI within the next 5 years (OR 1.93, 95% CI 1.76-3.2, p < 0.01).
Conclusion:
The IADL-x metric appears to be a valid approach for determining the risk of MCI based on one's position along a formal hierarchy of function.
More Related Videos
Related Concept Videos
Variation: Normal Distribution, Range, and Standard Deviation
Increasing Function
Cognitive Dissonance
Range
15.9; 16.1; 15.2; 14.8; 15.8; 15.9; 16.0; 15.5
Measurements of the amount of soda in a 16-ounce can vary since different subjects record these measurements or since the exact amount - 16 ounces of liquid, was not...
Normal Distribution
Normal Stress
When a rod is under axial loading, the internal forces and corresponding stress are normal to the plane of the section, so it is termed normal stress. It's important to...

