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[Therapy Resistant Fusarium Keratitis with Intraocular Involvement - Potential Sources of a Persisting Infection]

Karin U Löffler1, Frank G Holz2, Martina C Herwig-Carl1

  • 1Sektion Ophthalmopathologie, Universitäts-Augenklinik, Universitätsklinikum Bonn.

Klinische Monatsblatter Fur Augenheilkunde
|July 12, 2018
PubMed
Abstract

Insights

Fungal keratitis, often diagnosed late due to varied symptoms, can lead to severe outcomes like enucleation. Early diagnosis and aggressive surgical intervention, including large keratoplasty and lens capsule removal, are crucial for treating resistant fungal eye infections.

Area of Science:

  • Ophthalmology
  • Medical Mycology

Background:

  • Fungal keratitis presents with diverse clinical signs, often leading to delayed diagnosis.
  • Fungi are inherently resistant organisms, complicating treatment due to limited medication options.

Purpose of the Study:

  • To highlight the challenges and unfavorable outcomes in treating severe fungal keratitis.
  • To emphasize the importance of early diagnosis and comprehensive treatment strategies for fungal eye infections.

Main Methods:

  • Case report of a young female patient with Fusarium keratitis.
  • Detailed description of extensive medical and surgical interventions.
  • Histopathological examination of the enucleated globe.

Main Results:

  • The patient underwent enucleation despite extensive treatment for Fusarium keratitis.
  • Histology revealed significant post-inflammatory changes and minimal fungal elements in the lens capsule and Descemet's membrane.

Conclusions:

  • Fungal infections must be considered early in therapy-resistant keratitis cases.
  • Large-diameter keratoplasty and removal of the lens capsule are recommended surgical approaches to eradicate fungal reservoirs.

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