Effects of gamma-vinyl-GABA on the human electroencephalogram

Gamma-vinyl-GABA (GVG) is a new anticonvulsant drug that significantly raises the level of the gamma-aminobutyric acid in the brain (GABA). The effects of gamma-vinyl-GABA on the human electroencephalogram were studied to assess the role of GABAergic mechanisms on electrocortical activity. Serial EEGs were recorded in 15 epileptic patients undergoing a controlled clinical trial of gamma-vinyl-GABA. The effects of gamma-vinyl-GABA on alpha, beta, or theta activity, sleep spindles and epileptiform activity were studied. No changes could be detected in any of the intrinsic brain rhythms. Three patients showed a mild amelioration of epileptiform activity; no increase in epileptiform activity was seen.