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Current Status of Microbial Phenylethanoid Biosynthesis.

Song-Yi Kim1, Min Kyung Song1, Ju Hyun Jeon1

  • 1Department of Integrative Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Seoul 05029, Republic of Korea.

Journal of Microbiology and Biotechnology
|July 13, 2018
PubMed
Summary

Microbial synthesis of phenylethanoids, plant-derived compounds with diverse health benefits, is advancing rapidly. This review highlights recent progress in using engineered microbes for producing these valuable compounds.

Keywords:
Metabolic engineeringmicrobial productionphenylethanoids

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Area of Science:

  • Biotechnology and Synthetic Biology
  • Natural Product Chemistry

Background:

  • Phenylethanoids are plant-derived phenolic compounds with a C6-C2 skeleton.
  • These compounds, including 2-phenylethanol, tyrosol, and salidroside, exhibit significant antibacterial, anticancer, anti-inflammatory, neuroprotective, and anti-asthmatic properties.

Purpose of the Study:

  • To review recent advancements in the microbial synthesis of phenylethanoids.
  • To explore the potential of metabolic engineering and synthetic biology for producing phenylethanoids from alternative microbial sources.

Main Methods:

  • Review of recent scientific literature on microbial synthesis of phenylethanoids.
  • Analysis of metabolic engineering and synthetic biology strategies employed in microorganisms for phenylethanoid production.

Main Results:

  • Successful microbial synthesis of various phenylethanoids has been reported.
  • Engineered microbial systems offer a promising alternative for phenylethanoid production.

Conclusions:

  • Recent achievements demonstrate the feasibility of producing diverse phenylethanoids using microbial systems.
  • Further exploration of microbial production can facilitate the discovery of new biological activities of phenylethanoids.