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Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
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The impact of fetal umbilical artery Doppler pulsatility index on childhood respiratory function and atopy: a

Fionnuala Mone1, Andrew Thompson2, Moira C Stewart2

  • 1Obstetrics and Gynaecology, UCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|July 13, 2018
PubMed

Insights

Elevated fetal umbilical artery Doppler pulsatility index at 28 weeks gestation does not predict childhood asthma or atopy at age 12. These findings suggest respiratory conditions have complex, multifactorial causes.

Area of Science:

  • Obstetrics and Gynecology
  • Pediatrics
  • Respiratory Medicine

Background:

  • Fetal Doppler pulsatility index can indicate placental function.
  • Childhood respiratory diseases like asthma have complex origins.
  • Long-term effects of abnormal fetal Doppler findings require further investigation.

Purpose of the Study:

  • To investigate the association between elevated fetal umbilical artery Doppler pulsatility index and respiratory function in 12-year-old children.
  • To determine if abnormal fetal Doppler findings predict atopy in later childhood.
  • To explore correlations with spirometry, C-reactive protein, and leptin levels.

Main Methods:

  • Prospective case-control study comparing children with elevated vs. normal fetal umbilical artery Doppler pulsatility index (>90th vs. <90th centile).
  • Inclusion criteria: full-term delivery, appropriate growth for gestational age.
  • Outcome measures: asthma, atopy, spirometry (FEV1, FVC), serum C-reactive protein, and leptin, analyzed with multiple regression.

Main Results:

  • No significant association found between elevated fetal umbilical artery Doppler pulsatility index and asthma (p=0.47) or atopy (p=0.75) at age 12.
  • No correlation observed with spirometry measures (FEV1: p=0.96, FVC: p=0.98).
  • No association detected with elevated serum C-reactive protein (p=0.69) or leptin (p=0.20).

Conclusions:

  • Elevated umbilical artery Doppler pulsatility index at 28 weeks gestation, without prematurity or growth restriction, is not linked to impaired respiratory function or atopy at age 12.
  • These results support the multifactorial etiology of childhood respiratory diseases.
  • Further research into diverse etiological factors is warranted.

Keywords:
AsthmaC-reactive proteinchildrenleptinspirometry

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