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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
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Stabilized tetraether lipids based particles guided prophyrins photodynamic therapy
Gihan Mahmoud1,2, Jarmila Jedelská1, Samia Mohamed Omar3
1a Department of Pharmaceutics and Biopharmaceutics , University of Marburg , Marburg , Germany.
Drug Delivery
|July 13, 2018
Summary
Ultrastable tetraether lipids (TELs) liposomes improved Protoporphyrin IX (PpIX) delivery for photodynamic therapy (PDT). TEL-liposomes demonstrated sustained PpIX release and enhanced efficacy in vascular PDT models with minimal damage.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Photochemistry
Background:
- Photodynamic therapy (PDT) utilizes photosensitizers like Protoporphyrin IX (PpIX) for cancer treatment.
- Premature PpIX release causes toxicity and limits therapeutic outcomes in PDT.
- Developing stable delivery systems is crucial for effective PpIX-based PDT.
Purpose of the Study:
- To develop ultrastable tetraether lipids (TELs) based liposomes for improved Protoporphyrin IX (PpIX) delivery in photodynamic therapy (PDT).
- To investigate the physical state and release kinetics of PpIX within TEL-liposomes.
- To evaluate the efficacy and safety of TEL-liposome formulations in vascular and cellular PDT models.
Main Methods:
- Fabrication of ultrastable tetraether lipids (TELs) based liposomes encapsulating Protoporphyrin IX (PpIX).
- Characterization of PpIX aggregation and release kinetics using models like Baker & Lonsdale.
- Assessment of liposome stability in human serum albumin.
- In-ovo chick chorioallantoic membrane model for vascular photodynamic therapy (vPDT).
- In vitro cellular photodynamic therapy (cPDT) studies with varying radiant exposure doses.
Main Results:
- PpIX molecules were physically entrapped within the TEL liposome monolayer, preventing aggregation.
- TEL-liposomes exhibited a sustained release diffusion pattern of PpIX, fitting the Baker & Lonsdale model.
- TEL62mol% liposomes showed high stability in human serum albumin.
- TEL62mol% liposomes demonstrated effective localized vPDT in the chick chorioallantoic membrane model without significant vascular damage.
- Cellular PDT confirmed that PpIX in TEL-liposomes could be modulated by different radiant exposure doses.
Conclusions:
- Ultrastable tetraether lipids (TELs) based liposomes offer a promising strategy for controlled Protoporphyrin IX (PpIX) delivery in photodynamic therapy (PDT).
- TEL-liposomes enhance PpIX stability and efficacy, particularly in vascular PDT, while minimizing off-target toxicity.
- The developed liposomal formulation allows for tunable photo-responses in cellular PDT applications.
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