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Updated: Feb 7, 2026

Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations
Published on: January 8, 2013
Modelling of the ICF core sets for chronic ischemic heart disease using the LASSO model in Chinese patients
Meng You1, Wen Fang2, Xu Wang1
1Collaborative Innovation Center of Judicial Civilization, Key Laboratory of Evidence Science, China University of Political Science and Law, Ministry of Education, 25 Xitucheng Road, Beijing, 100040, China.
Insights
This study explored how functioning areas are linked in Chinese patients with chronic ischemic heart disease (CIHD). Key findings highlight the impact on physical functions, social interactions, and the importance of support systems for rehabilitation.
Area of Science:
- Cardiology
- Rehabilitation Medicine
- Health Services Research
Background:
- Chronic ischemic heart disease (CIHD) significantly impacts patient functioning.
- Understanding the interrelationships between different functional domains in CIHD is crucial for effective management.
Purpose of the Study:
- To investigate the associations among International Classification of Functioning, Disability, and Health (ICF) core sets in Chinese CIHD patients.
- To utilize the least absolute shrinkage and selection operator (LASSO) model for analyzing these associations.
Main Methods:
- Prospective study of 120 CIHD patients.
- Utilized the ICF core sets checklist for CIHD (Chinese version) to assess functioning.
- Applied LASSO generalized linear models and graphical modeling to identify variable dependencies.
Main Results:
- Physical functioning, including muscle endurance, cardiovascular sensations, and heart/blood vessel functions, were most impaired.
- "Recreation and leisure" and "intimate relationships" were significantly affected.
- Social support and community connections were vital for functional status; economic and family relationships were less impacted.
Conclusions:
- Graphical modeling effectively illustrates functional associations in CIHD.
- Findings provide a basis for improving rehabilitation strategies and understanding functioning in Chinese CIHD populations.
Background:
This study aimed to examine the associations among the International Classification of Functioning, Disability, and Health (ICF) core sets relevant to chronic ischemic heart disease (CIHD) using the least absolute shrinkage and selection operator (LASSO) model based on the ICF core sets scale in Chinese patients.
Methods:
This was a prospective study of 120 patients with CIHD selected from January 2013 to June 2014 at the Fada Institute of Forensic Medicine & Science (Beijing, China). Functioning was qualified using the ICF core sets checklist for CIHD (Chinese version). The variables of core set categories of the ICF assessment scale for CIHD were entered into the LASSO model for mining dependencies among those variables. Graphical modeling was applied using LASSO generalized linear models.
Results:
"Muscle endurance functions", "sensations associated with cardiovascular and respiratory functions", "blood vessel functions", and "heart functions" were the most injured in CIHD status. "Recreation and leisure" and "intimate relationships" were the most affected in CIHD status. "General social support services, systems, and policies" and "acquaintances, peers, colleagues, neighbors, and community members" were important for the outcome of functional status of the CIHD patient. "Economic self-sufficiency" and "family relationships" of the CIHD patient were not undermined in most cases.
Conclusions:
Graphical modeling can be used to describe associations between different areas of functioning in CIHD patients. The results suggest that these associations could be used as basis to improve rehabilitation and provide a deeper understanding of functioning in Chinese CIHD patients.
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