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Related Concept Videos

Filtration and Urine Formation01:32

Filtration and Urine Formation

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The function of the kidneys is to filter, reabsorb, secrete, and excrete. Every day the kidneys filter nearly 180 liters of blood, initially removing water and solutes but ultimately returning nearly all filtrates into circulation with the help of osmoregulatory hormones. This process removes wastes and toxins but is also crucial to maintain water and electrolyte levels. Most of these functions are performed by the tiny but numerous nephrons contained within the kidneys.
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Urine Studies II: Urine Culture and Sensitivity Test01:26

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A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Physiology of Urine Formation01:24

Physiology of Urine Formation

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Urine formation is an essential function of the human body. It plays a critical role in maintaining homeostasis by regulating the volume and composition of body fluids. The kidneys, the primary organs involved in this process, filter blood to remove waste products and excess substances, ultimately producing urine.
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
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Formation of Concentrated Urine01:23

Formation of Concentrated Urine

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There is a gradient of solutes in the interstitial fluid from the renal cortex through the medulla, known as the medullary osmotic gradient. The juxtamedullary nephrons establish and maintain this gradient using countercurrent mechanisms with loops extending deep into the medulla. These nephrons also use countercurrent mechanisms to regulate urine volume and concentration. The interaction between the descending and ascending limbs of the nephron loop creates an osmotic gradient through...
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Urine Studies I: Urinalysis01:29

Urine Studies I: Urinalysis

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Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
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Related Experiment Video

Updated: Feb 7, 2026

Exon Skipping in Directly Reprogrammed Myotubes Obtained from Human Urine-Derived Cells
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Urine-derived cells for human cell therapy.

Nimshitha Pavathuparambil Abdul Manaph1,2,3, Mohammed Al-Hawwas2, Larisa Bobrovskaya2

  • 1Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, 5000, South Australia.

Stem Cell Research & Therapy
|July 13, 2018
PubMed
Summary
This summary is machine-generated.

Human urine-derived cells offer a promising, non-invasive source for cell therapy. These cells are easily isolated and cultured, presenting a cost-effective alternative to traditional methods for regenerative medicine applications.

Keywords:
DifferentiationRenal cellsStem cellsTherapyUrine

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Area of Science:

  • Regenerative Medicine
  • Cell Biology
  • Urology

Background:

  • Current cell therapy relies on invasive sample collection and complex, expensive culture methods.
  • Existing cell sources from blood, skin, and hair require invasive procedures and extensive in-vitro expansion.
  • Urine-derived cells present a viable alternative, obtainable through non-invasive methods.

Purpose of the Study:

  • To review the characteristics and therapeutic potential of urine-derived cells.
  • To explore their application in human cell therapy and regenerative medicine.
  • To highlight urine-derived cells as a superior source compared to conventional stem cells.

Main Methods:

  • Review of existing literature on urine-derived cell isolation and culture.
  • Analysis of gene profiles and multipotent potential of urine stem cells.
  • Discussion of transdifferentiation and differentiation capabilities of urine-derived cells.

Main Results:

  • Urine-derived cells, particularly urine stem cells, can be isolated using simple, cost-effective techniques.
  • These cells possess a favorable gene profile and inherent multipotent potential.
  • Urine-derived cells can be differentiated into various cell types for therapeutic use.

Conclusions:

  • Urine-derived cells are a prospective source for generating functional, lineage-specific cells for clinical translation.
  • Their non-invasive isolation and cost-effective culture offer significant advantages for cell therapy.
  • Further research and optimization of urine-derived cells hold promise for regenerative medicine.