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Hypomagnesaemia and pregnancy.

Adam Morton1

  • 1Mater Hospital, Raymond Tce, Brisbane, Australia.

Obstetric Medicine
|July 13, 2018
PubMed
Summary
This summary is machine-generated.

Hypomagnesaemia, or low magnesium, is common in pregnancy. This review examines its unclear association with adverse pregnancy outcomes in humans, despite animal study evidence.

Keywords:
Gitelman syndromeHypomagnesaemiaadverse pregnancy outcomesdiabetes mellitushypertensive disorders of pregnancyjejunoileal bypassphysiologypremature laboursmall for gestational age

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Nutritional Science

Background:

  • Hypomagnesaemia is prevalent in pregnancy, especially in developing regions.
  • Magnesium is frequently used therapeutically during pregnancy.
  • Animal studies suggest a link between hypomagnesaemia and adverse pregnancy outcomes.

Purpose of the Study:

  • To clarify the association between hypomagnesaemia and pregnancy complications in humans.
  • To review magnesium physiology during pregnancy.
  • To evaluate hypomagnesaemia's role in adverse pregnancy outcomes.

Main Methods:

  • Presentation of three case reports of pregnancies with moderate-severe hypomagnesaemia.
  • Review of existing literature on magnesium's role in pregnancy.
  • Discussion of magnesium physiology in the context of pregnancy.

Main Results:

  • Presents cases illustrating potential clinical significance of hypomagnesaemia in pregnancy.
  • Highlights the lack of definitive human data linking hypomagnesaemia to adverse outcomes.
  • Discusses the complex relationship between magnesium levels and pregnancy health.

Conclusions:

  • The direct causal link between hypomagnesaemia and adverse pregnancy outcomes in humans remains uncertain.
  • Hypomagnesaemia may be a consequence or epiphenomenon rather than a direct cause of complications.
  • Further research is needed to elucidate magnesium's precise role in human pregnancy health.