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Emergence of G8P[6] rotavirus strains in Korean neonates

Su-Kyung Lee1, Seoheui Choi2, Seon-Hee Shin2

  • 11Department of Laboratory Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, 7, Keunjaebong-gil, Hwaseong-si, Gyeonggi-do 18450 South Korea.

Gut Pathogens
|July 13, 2018
PubMed

Insights

Rotavirus G8P[6] strains, a novel genotype, were identified in Korean neonates. These strains, distinct from common vaccine types, may arise from reassortment events, necessitating ongoing epidemiological surveillance.

Area of Science:

  • Virology
  • Molecular Epidemiology
  • Pediatric Infectious Diseases

Background:

  • Rotaviruses are a leading cause of severe gastroenteritis in children globally.
  • Understanding rotavirus strain distribution is crucial for vaccine development and diagnostics.
  • Genotypic variations necessitate continuous monitoring of circulating strains.

Purpose of the Study:

  • To investigate the VP4 and VP7 capsid genotypes of rotaviruses in Korean neonates.
  • To determine the molecular epidemiology of rotavirus strains in a neonatal intensive care unit.

Main Methods:

  • Analysis of 211 stool specimens from neonates (September 2017 - March 2018).
  • Detection and genotyping of rotavirus using VP4 and VP7 capsid genes.
  • Nucleotide sequence analysis for genetic relatedness.

Main Results:

  • Rotavirus was detected in 7.1% of specimens.
  • The predominant genotype identified was G8P[6] (73.3%), followed by G4P[6] (26.7%).
  • G8 sequences showed similarity to Vietnamese strains; P[6] sequences matched Korean strains, suggesting reassortment.

Conclusions:

  • This study reports the first high-frequency detection of rotavirus G8P[6] in Korean neonates.
  • The emergence of G8P[6] strains is likely due to reassortment between regional G8P[8] and local G4P[6] strains.
  • Continuous surveillance is required to ascertain the prevalence and significance of this unusual rotavirus genotype.
Abstract

Keywords:
G8P[6]GenotypeKoreanNeonateRotavirus

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