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Related Concept Videos

Lung Capacity01:47

Lung Capacity

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Pleura of the Lungs01:13

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The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
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Tissue Transplantation01:24

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Kidney Transplant I: Introduction01:28

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Gross Anatomy of the Lungs01:17

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The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Updated: Feb 7, 2026

Orthotopic Left Lung Transplantation in Rats
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Orthotopic Left Lung Transplantation in Rats

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Malignancies after lung transplantation.

Anne Olland1,2, Pierre-Emmanuel Falcoz1,2, Gilbert Massard1,2

  • 1Lung Transplantation Group, University Hospital Strasbourg, Strasbourg, France.

Journal of Thoracic Disease
|July 13, 2018
PubMed
Summary
This summary is machine-generated.

Lung transplantation improves survival but increases cancer risk due to immunosuppression. Post-transplant malignancies are a significant cause of death, requiring careful management and risk factor consideration.

Keywords:
Lung transplantationbronchogenic carcinomaimmunosuppressive regimenmalignanciesrisk factors

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Area of Science:

  • Medical research
  • Transplantation medicine
  • Oncology

Background:

  • Lung transplantation is a life-saving treatment for end-stage respiratory disease, with outcomes improving due to surgical experience and immunosuppressive drugs.
  • While effective, immunosuppressive therapy carries risks including malignancy, hypertension, diabetes, and renal dysfunction.
  • Malignancies are a major cause of mortality post-lung transplantation, becoming the third leading cause of death within the first year.

Purpose of the Study:

  • To review the types of malignancies that arise after lung transplantation.
  • To discuss bronchogenic carcinoma in explanted, native, and transplanted lungs.
  • To explore risk factors for post-transplant cancers and provide treatment recommendations.

Main Methods:

  • Literature review of malignancies following lung transplantation.
  • Analysis of different lung transplant techniques and their impact on cancer development.
  • Discussion of immunosuppressive, occupational, and environmental risk factors, including smoking.

Main Results:

  • Malignancies are a significant cause of late mortality after lung transplantation.
  • Specific types of bronchogenic carcinoma can occur in various lung locations (native, graft, explanted).
  • Immunosuppression, smoking, and environmental factors are key risk factors for post-transplant cancers.

Conclusions:

  • Malignancies pose a substantial threat to long-term survival after lung transplantation.
  • Understanding and mitigating risk factors, particularly immunosuppression and smoking, is crucial.
  • Developing integrated treatment strategies for post-transplant malignancies is essential for improving patient outcomes.