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An Overview on Renoprotective Effects of Thymoquinone

Hanieh Shaterzadeh-Yazdi1,2, Mohammad-Foad Noorbakhsh3, Saeed Samarghandian4

  • 1Research Center of Pardis Hospital, Mashhad, Iran.

Kidney Diseases (Basel, Switzerland)
|July 13, 2018
PubMed
Abstract

Insights

Thymoquinone (TQ), derived from black seeds, demonstrates significant antioxidant and anti-inflammatory properties. These effects show promise in protecting against various kidney diseases, including those caused by ischemia, diabetes, and toxins.

Area of Science:

  • Pharmacology
  • Nephrology
  • Natural Products Chemistry

Background:

  • Kidneys are vital organs responsible for waste removal, electrolyte balance, blood pressure regulation, and red blood cell production.
  • Kidney diseases can arise from ischemia/reperfusion injury, diabetes, and nephrotoxic agents, often involving oxidative stress and inflammation.
  • Natural antioxidants are traditionally used to manage renal failure, with a perception of minimal side effects.

Purpose of the Study:

  • To review the protective roles and mechanisms of Thymoquinone (TQ) against various renal disorders.
  • To explore the therapeutic potential of TQ, the active component of *Nigella sativa*, in kidney disease.

Main Methods:

  • A literature search was conducted using terms such as TQ, antioxidant, renal ischemia-reperfusion, diabetic nephropathy, and nephrotoxic agent.
  • The review focused on experimental and in vitro models of kidney diseases involving inflammation and oxidative stress.

Main Results:

  • Thymoquinone (TQ) exhibited notable anti-inflammatory and antioxidant properties in preclinical models.
  • These properties suggest a protective effect of TQ against kidney damage induced by various pathological conditions.

Conclusions:

  • TQ shows potential therapeutic benefits in animal and in vitro models of renal diseases.
  • Further well-designed clinical trials in humans are necessary to validate the efficacy of TQ for kidney disorders.
Keywords:
InflammationKidneyOxidative stressRenoprotective effectsThymoquinone

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