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A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury
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Physical Activity Does Not Reduce Aortic Valve Stenosis Incidence.

Philip Sarajlic1, Alicja Wolk2,3, Magnus Bäck1,4

  • 1Center for Molecular Medicine, Department of Medicine, Karolinska Institutet.

Circulation Journal : Official Journal of the Japanese Circulation Society
|July 13, 2018
PubMed
Summary

Regular physical activity does not appear to prevent aortic valve stenosis (AVS). This study found no link between exercise or walking/bicycling and reduced AVS risk in adults.

Keywords:
Aortic valve stenosisPhysical activityProspective studies

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Area of Science:

  • Cardiology
  • Preventive Medicine
  • Epidemiology

Background:

  • Physical activity is known to reduce risks for coronary and cerebrovascular diseases.
  • The role of physical activity in preventing aortic valve stenosis (AVS) remains uncertain.

Purpose of the Study:

  • To investigate the association between physical activity levels and the risk of developing aortic valve stenosis (AVS).

Main Methods:

  • A cohort study involving 69,288 adults was conducted.
  • Follow-up averaged 15.3 years, during which 1,238 cases of AVS were diagnosed.
  • Hazard ratios were calculated for associations between AVS and walking/bicycling or exercise.

Main Results:

  • No significant association was found between regular walking/bicycling (≥1 h/day) and AVS risk (HR 0.92, 95% CI 0.74-1.15).
  • No significant association was observed between regular exercise (≥4 hs/week) and AVS risk (HR 1.18, 95% CI 0.97-1.43).

Conclusions:

  • Physical activity, including walking, bicycling, and exercise, did not demonstrate a preventative effect on the incidence of aortic valve stenosis.