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Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Published on: April 4, 2018

Recent Progress in the Development of Microfluidic Vascular Models.

Kae Sato¹, Kiichi Sato²

¹Department of Chemical and Biological Sciences, Faculty of Science, Japan Women's University.

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry

|July 13, 2018

Summary

This summary is machine-generated.

This review explores microfluidic vascular models, which mimic blood vessel functions like material exchange and fluid shear stress. These models are crucial for understanding tissue environments and disease progression.

Keywords:

Microfluidic device bioassay blood vessel cell culture cell-based assay endothelial cell extracellular matrix microchip organ-on-a-chip

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Area of Science:

Biomedical Engineering
Physiology
Microfluidics

Background:

Blood vessels are vital for the circulatory system, supplying tissues and facilitating material exchange.
Vascular structures vary in size and cell type, adapted to specific functions.
Recent advancements focus on microfluidic models to study vascular biology.

Purpose of the Study:

To review recent studies on microfluidic vascular models.
To classify different types of microfluidic vascular model structures.
To highlight the functions and applications of these models in research.

Main Methods:

Classification of microfluidic vascular models into poly(dimethylsiloxane) and hydrogel microchannels, and self-assembled networks.
Implementation of basic vascular phenomena such as fluid shear stress, cell strain, and interstitial flow.
Co-culture of endothelial cells with other cell types (smooth muscle cells, pericytes, fibroblasts) within extracellular matrices.

Main Results:

Demonstration of key vascular functions including endothelial permeation, angiogenesis, and thrombosis in microfluidic models.
Successful co-culture of various cell types within engineered vascular environments.
Application of models to study organ-specific vascular systems (brain, lung, liver, kidney, placenta) and cancer.

Conclusions:

Microfluidic vascular models offer powerful platforms for studying complex vascular biology.
These models replicate essential physiological and pathological processes.
They hold significant potential for advancing research in various medical fields, including disease modeling and drug discovery.