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Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells
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Programmed cell death in the human ovary.

Serena Marcozzi1, Valerio Rossi1, Antonietta Salustri1

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Ovarian follicle development involves programmed cell death (PCD). This review details atresia, the primary fate of ovarian follicles, and its regulation during human folliculogenesis.

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Area of Science:

  • Reproductive biology
  • Cellular biology
  • Gynecology

Background:

  • Folliculogenesis is a complex process involving oocyte and follicular cell survival and death.
  • Programmed cell death (PCD) is implicated in follicle development.
  • Atresia is the main pathway for ovarian follicle elimination.

Purpose of the Study:

  • To review the mechanisms of atresia during human folliculogenesis.
  • To describe atresia from birth to adulthood.
  • To compare human and mammalian atresia.

Main Methods:

  • Literature review of folliculogenesis and atresia.
  • Description of programmed cell death mechanisms.
  • Comparative analysis of human and mammalian data.

Main Results:

  • Atresia is a critical process regulating the number of follicles.
  • Multiple PCD pathways contribute to atresia.
  • Atresia occurs throughout folliculogenesis, from primordial to preovulatory stages.

Conclusions:

  • Understanding atresia mechanisms is crucial for reproductive health.
  • Further research is needed to fully elucidate PCD in folliculogenesis.
  • Atresia regulation is key to maintaining ovarian reserve.