Related Experiment Video

Updated: Feb 7, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.5K

Disseminated intravascular coagulation: an update on pathogenesis and diagnosis

Marcel Levi1,2, Suthesh Sivapalaratnam3,4

  • 1a Department of Medicine , University College London Hospitals NHS Foundation Trust , London , United Kingdom.

Expert Review of Hematology
|July 13, 2018
PubMed

Insights

Disseminated intravascular coagulation (DIC) involves systemic coagulation activation, often seen in sepsis or trauma. Recent research offers better understanding of DIC pathophysiology and improved diagnostic tools for clinical practice.

Area of Science:

  • Hematology
  • Critical Care Medicine
  • Pathophysiology

Background:

  • Systemic activation of the hemostatic system is common in various clinical conditions.
  • Severe coagulation activation in settings like sepsis, trauma, or malignancy can lead to disseminated intravascular coagulation (DIC).

Purpose of the Study:

  • To review the clinical manifestations, relevance, and precipitating conditions of DIC.
  • To explore the pathogenetic pathways underlying hemostatic derangement in DIC.
  • To discuss the diagnostic approach to DIC.

Main Methods:

  • Review of clinical and experimental studies on DIC.
  • Analysis of pathogenetic pathways and clinical manifestations.
  • Evaluation of diagnostic algorithms for DIC.

Main Results:

  • Recent insights have improved understanding of DIC pathophysiology.
  • New adjunctive treatment strategies are emerging based on this understanding.
  • Validated, simple diagnostic algorithms for DIC are now available.

Conclusions:

  • Enhanced understanding of DIC pathophysiology provides targets for improved treatment.
  • Validated diagnostic algorithms facilitate clinical diagnosis of DIC.
  • DIC remains a critical complication in various severe clinical conditions.
Abstract

Keywords:
Anticoagulantscoagulationcoagulation factorsdisseminated intravascular coagulationfibrin degradation productsfibrinolysisplatelets

More Related Videos

In Ovo Intravascular Injection in Chicken Embryos07:00

In Ovo Intravascular Injection in Chicken Embryos

Published on: June 3, 2022

7.3K
Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination05:39

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

Published on: February 9, 2021

3.7K

Related Concept Videos

Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
1.4K
Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
10.6K
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
662
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.4K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
888
Nursing Diagnosis01:22

Nursing Diagnosis

Following assessment, a nursing diagnosis is the next step in the nursing process. It begins after the nurse has collected and recorded the patient data. The purpose of diagnosing is to identify how the client responds to actual or potential health processes, identify factors that bestow or that cause health problems, the etiologies, and identify resources or strengths the individual, group, or community can draw on to prevent or resolve problems.
The nursing diagnosis focuses on evidence-based...
4.2K