Utilizing proteomics to understand and define hypertension: where are we and where do we go?

Area of Science:

• Cardiovascular Science
• Proteomics
• Hypertension Research

Background:

• Hypertension is a complex cardiovascular disorder with unmet needs in prevention and therapy.
• Discovering novel pathogenetic principles is challenging due to multifactorial mechanisms.
• Reducing the global burden of hypertension-related diseases requires improved detection and treatment.

Purpose of the Study:

• To review the application of proteomic techniques in understanding hypertension.
• To explore proteomic studies in experimental models and human subjects.
• To discuss the implications of proteomics for precision medicine in hypertension.

Main Methods:

• Proteomic techniques applied to experimental hypertension models (rodents).
• Proteomic studies in humans focusing on prediction and detection of organ damage (heart failure, renal disease).
• Analysis of proteomic data in primary hypertension and hypertensive disorders of pregnancy (preeclampsia).

Main Results:

• Proteomics has been used in experimental models to unravel blood pressure control and end-organ damage mechanisms.
• Human proteomic studies primarily focus on predicting and detecting organ damage.
• Few studies address primary human hypertension, with more data available for preeclampsia.

Conclusions:

• Proteomics holds potential for understanding hypertension and guiding precision medicine.
• Progress in applying proteomics to hypertension research has been moderate.
• Standardized, large-scale studies are essential for maximizing proteomics' potential in cardiovascular diseases.