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Updated: Feb 7, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
Published on: February 21, 2014
Regulation and functions of MicroRNA-149 in human cancers
Yingru Zhi1, Hao Zhou2, Abudoureyimu Mubalake1
1Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
Abstract:
MicroRNAs are small non-coding RNAs that play critical roles in the regulatory mechanisms involving cell differentiation, proliferation, apoptosis and tumorigenesis. Recent research efforts have been conducted to apply these discoveries into clinical functions, including the early diagnosis and therapeutic outcome of patients with cancer. Previous studies have shown that microRNA-149 (miR-149) is dysregulated in various human cancers and exerts its effects on tumorigenesis and tumour progression. In this review, we summarized the potential roles of miR-149 dysregulation and its target genes during tumorigenesis and clinical treatment of human cancers.
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