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Sexually Transmitted Infections01:26

Sexually Transmitted Infections

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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

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Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
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Development of the Sexual Organs in the Embryo and Fetus01:15

Development of the Sexual Organs in the Embryo and Fetus

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Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
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Induced-fit Model01:13

Induced-fit Model

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Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Electric Dipoles01:28

Induced Electric Dipoles

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A permanent electric dipole orients itself along an external electric field. This rotation can be quantified by defining the potential energy because the external torque does work in rotating it. Then, the potential energy is minimum at the parallel configuration and maximum at the antiparallel configuration. While the former is a stable equilibrium, the latter is an unstable equilibrium.
Since the absolute value of potential energy holds no physical meaning, its zero value can be chosen as per...
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Related Experiment Video

Updated: Feb 7, 2026

Assessment of Sexual Behavior of Male Mice
04:38

Assessment of Sexual Behavior of Male Mice

Published on: March 5, 2020

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Sexual Dysfunctions Induced by Pregabalin.

Sherifa Ahmed Hamed1

  • 1Department of Neurology and Psychiatry, Assiut University Hospital, Assiut, Egypt.

Clinical Neuropharmacology
|July 13, 2018
PubMed
Summary

Sexual dysfunction is a common side effect of pregabalin (PGB). This study found that pregabalin can cause erectile dysfunction, anorgasmia, and loss of libido, even at low doses. These side effects improve after discontinuing PGB.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Clinical Medicine

Background:

  • Pregabalin (PGB), a gabapentinoid, is FDA-approved for epilepsy and neuropathic pain.
  • It is also used off-label for anxiety, fibromyalgia, and headaches.
  • Sexual dysfunction (SD) is a potential adverse effect of PGB, though infrequently reported and often dose-related for gabapentin.

Purpose of the Study:

  • To determine the frequency and types of SDs induced by PGB.
  • To investigate the temporal relationship between PGB use and the onset of SDs.

Main Methods:

  • A case series of 75 patients treated with PGB for various indications was analyzed.
  • Patients who developed SDs during PGB treatment were identified.

Main Results:

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  • SDs were observed in 41.33% of patients (31/75).
  • Reported SDs included erectile dysfunction (51.61%), anorgasmia (32.26%), and loss of libido (35.48%).
  • SDs occurred within weeks of starting PGB at low therapeutic doses (50-100 mg/d) and were not dose-related.

Conclusions:

  • SDs are not infrequent adverse effects of PGB therapy.
  • PGB can induce erectile dysfunction, loss of libido, and anorgasmia.
  • Clinicians should discuss potential sexual side effects with patients undergoing PGB treatment.