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Related Experiment Video

Updated: Feb 7, 2026

Immunofluorescent Labeling of Plant Virus and Insect Vector Proteins in Hemipteran Guts
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STING: From Mammals to Insects.

Yang Qiu1, Xi Zhou1

  • 1State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.

Cell Host & Microbe
|July 13, 2018
PubMed
Summary

STING protein is crucial for innate immunity in mammals. New research shows Drosophila STING is essential for fighting viral and bacterial infections, highlighting its conserved role in defense.

Area of Science:

  • Immunology
  • Molecular Biology
  • Infectious Diseases

Background:

  • STING (stimulator of interferon genes) is a critical protein in the innate immune system of mammals.
  • It plays a central role in detecting intracellular pathogens and initiating immune responses.

Purpose of the Study:

  • To investigate the role of STING in invertebrate immunity.
  • To determine if STING functions similarly in Drosophila as it does in mammals.

Main Methods:

  • Utilized genetic analysis in Drosophila melanogaster.
  • Examined the effects of STING deficiency on antiviral and antibacterial defenses.

Main Results:

  • Drosophila STING was found to be essential for effective antiviral defense.

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  • Drosophila STING was also shown to be required for antibacterial immunity.

    • Conclusions:

    • The findings demonstrate a conserved role for STING in innate immunity across species.
    • STING is a key mediator of both antiviral and antibacterial responses in Drosophila, similar to its function in mammals.