Typhoon-Related Post-Traumatic Stress Disorder and Trauma Might Lead to Functional Integration Abnormalities in
Jun Ke1, Li Zhang2, Rongfeng Qi1
1Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Summary
Trauma alters brain networks, with distinct connectivity changes in post-traumatic stress disorder (PTSD) patients and trauma-exposed individuals. These findings reveal differing compensatory mechanisms in brain resting-state networks.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Previous studies suggest altered functional connectivity in default mode network (DMN), executive control network (ECN), and salience network (SN) in post-traumatic stress disorder (PTSD).
- Region of interest (ROI) approaches have limitations in fully understanding network interactions.
Purpose of the Study:
- To investigate alterations in intranetwork and internetwork brain connectivity using a data-driven approach.
- To compare brain connectivity in patients with PTSD, trauma-exposed controls (TEC), and healthy controls (HC).
Main Methods:
- Resting-state functional MRI data analyzed using independent component analysis (ICA).
- Examined functional connectivity within DMN, ECN, SN, and effective connectivity between these networks.
- Compared connectivity patterns across 27 PTSD patients, 33 TEC, and 30 HC groups.
Main Results:
- Trauma-exposed controls (TEC) showed altered DMN connectivity (superior frontal gyrus) and SN connectivity (superior temporal gyrus/posterior insula) compared to healthy controls (HC).
- PTSD patients exhibited altered ECN connectivity (middle frontal gyrus, supplementary motor area) and SN connectivity (inferior frontal gyrus/anterior insula) compared to TEC.
- PTSD group showed increased excitatory influence from ECN to DMN, while TEC showed increased inhibitory influence from DMN to ECN compared to HC.
Conclusions:
- Intranetwork connectivity within DMN and SN is altered in traumatized individuals, regardless of PTSD diagnosis.
- PTSD patients display distinct alterations in ECN intranetwork connectivity and effective connectivity between ECN and DMN.
- Altered effective connectivity between DMN and ECN suggests different compensatory strategies in PTSD patients and TEC.
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