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Updated: Feb 7, 2026

Establishing Fungal Entomopathogens as Endophytes: Towards Endophytic Biological Control
Published on: April 11, 2013
Two new tetracyclic triterpenoids from the endophytic fungus Hypoxylon sp. 6269
Han-Qiao Liang1,2, Da-Wei Zhang1,3, Shun-Xing Guo1
1a The Key Laboratory of Bioactive Substance and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100193 , China.
Abstract:
Two new tetracyclic triterpenoids, integracide E (1) and isointegracide E (2), as well as three known secondary metabolites (i.e. integracide A (3), 2-deoxyintegracide A (4) and 2-deoxyintegracide B (5)), were isolated from mycelium of the endophytic fungus Hypoxylon sp. 6269. Structures were determined by a combination of 1D and 2D NMR techniques and mass spectrometry. All of the compounds were tested for their anti-HIV-1 integrase activities.
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