Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gustation01:43

Gustation

52.4K
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
52.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Grammatical evolution-based design of nucleotic analogs for SARS-CoV-2's replication-transcription complex.

Physical chemistry chemical physics : PCCP·2026
Same author

Evaluation of 3',4'-Di-<i>O</i>-acetyl-<i>cis</i>-khellactone as a Putative Antagonist of PPARγ Using Experimental and Computational Modeling.

Biomolecules·2026
Same author

Ready BODIPY-Tagging of Carboxylic Acids.

The Journal of organic chemistry·2026
Same author

Falcarindiol from <i>Eryngium heterophyllum</i> Engelm. and <i>Eryngium pectinatum</i> C. Presl ex DC.: absolute configuration assignment and evaluation of its antihyperlipidemic activity.

Natural product research·2026
Same author

Supported Keggin anion catalyst: a study of its multifunctionality in retro-aldol condensation of 2<i>H</i>-chromenes.

Dalton transactions (Cambridge, England : 2003)·2026
Same author

Shared multicellular injury programs of acute and chronic kidney disease enable mechanistic patient stratification.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Feb 7, 2026

Source and Route of Pyrrolizidine Alkaloid Contamination in Tea Samples
06:04

Source and Route of Pyrrolizidine Alkaloid Contamination in Tea Samples

Published on: September 28, 2022

2.5K

Pyrrolizidine Alkaloids.

Joaquín Tamariz1, Eleuterio Burgueño-Tapia1, Miguel A Vázquez2

  • 1Departamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N, 11340 Mexico City, Mexico.

The Alkaloids. Chemistry and Biology
|July 14, 2018
PubMed
Summary

Pyrrolizidine alkaloids (PAs) are toxic plant compounds with significant biological activity. This review covers their occurrence, biosynthesis, toxicity, pharmacology, and synthetic chemistry challenges.

Keywords:
BiosynthesisGlycosidase inhibitionHepatotoxicityNatural occurrenceNecine basesPyrrolizidine alkaloidsPyrrolizidine synthesis

More Related Videos

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
09:36

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques

Published on: March 8, 2024

1.5K
Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry
08:56

Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry

Published on: November 22, 2024

1.5K

Related Experiment Videos

Last Updated: Feb 7, 2026

Source and Route of Pyrrolizidine Alkaloid Contamination in Tea Samples
06:04

Source and Route of Pyrrolizidine Alkaloid Contamination in Tea Samples

Published on: September 28, 2022

2.5K
Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
09:36

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques

Published on: March 8, 2024

1.5K
Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry
08:56

Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry

Published on: November 22, 2024

1.5K

Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Organic Synthesis

Background:

  • Pyrrolizidine alkaloids (PAs) are naturally occurring compounds found in various plants.
  • These alkaloids are of significant scientific interest due to their pronounced toxicity and diverse biological activities.
  • The complex pyrrolizidine scaffold presents a considerable synthetic challenge.

Purpose of the Study:

  • To provide a comprehensive review of pyrrolizidine alkaloids (PAs) from 1995 to the present.
  • To consolidate information on PA occurrence, biosynthesis, toxicity, and pharmacological properties.
  • To highlight advancements in the chemical synthesis of the pyrrolizidine core structure.

Main Methods:

  • Literature review encompassing scientific publications from 1995 to date.
  • Analysis of studies detailing PA occurrence, biosynthesis pathways, and toxicological profiles (hepatotoxicity, genotoxicity, tumorigenicity).
  • Examination of research on PA biological activities, including glycosidase inhibitory effects and synthetic strategies.

Main Results:

  • PAs exhibit significant toxicity, including hepatotoxicity, genotoxicity, and tumorigenicity.
  • These compounds display various biological activities, notably glycosidase inhibitory properties.
  • Diverse synthetic strategies for the pyrrolizidine scaffold have been developed, utilizing amino-based substrates, pyrroles, and pyrrolidine derivatives.

Conclusions:

  • Pyrrolizidine alkaloids are a critical class of natural products with complex chemistry and significant toxicological and pharmacological implications.
  • Continued research into PA synthesis is essential for understanding their biological roles and developing potential therapeutic agents.
  • This review serves as a valuable resource for researchers investigating the multifaceted nature of pyrrolizidine alkaloids.