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Related Experiment Videos

Follicular development: lessons learned from human in vitro fertilization.

A H DeCherney, B C Tarlatzis, N Laufer

    American Journal of Obstetrics and Gynecology
    |December 15, 1985
    PubMed
    Summary

    In vitro fertilization (IVF) research reveals poor correlation between follicle size and estrogen production, indicating follicular asynchrony. Cyclic adenosine monophosphate in follicular fluid predicts pregnancy success in IVF-embryo transfer cycles.

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    Ultrasound and hematological changes during early luteal phase in women at high risk for developing ovarian hyperstimulation syndrome.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2017

    Area of Science:

    • Reproductive Endocrinology
    • In Vitro Fertilization
    • Ovarian Physiology

    Background:

    • In vitro fertilization (IVF) provides novel insights into ovulation induction, folliculogenesis, and luteal phase dynamics.
    • Sequential monitoring via blood markers, ultrasound, and follicular fluid analysis enhances understanding of stimulated reproductive cycles.

    Purpose of the Study:

    • To investigate the relationship between follicular phase estradiol levels and ultrasound findings in stimulated IVF cycles.
    • To identify predictive biochemical markers for pregnancy in IVF-embryo transfer (IVF-ET) cycles.
    • To clarify the factors influencing luteal phase events in assisted reproductive technology.

    Main Methods:

    • Evaluation of serum estradiol levels and ultrasound measurements during the follicular phase of stimulated IVF cycles.

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  • Analysis of biochemical markers, including cyclic adenosine monophosphate, in follicular fluid.
  • Assessment of luteal phase events considering granulosa cell aspiration, progesterone supplementation, and estradiol levels.

    • Main Results:

    • A poor correlation was observed between follicle size/number and estrogen production, suggesting follicular asynchrony.
    • Cyclic adenosine monophosphate in follicular fluid demonstrated significant predictive value for pregnancy in IVF-ET.
    • Luteal phase patterns remain unclear due to controversial effects of granulosa cell aspiration, progesterone, and estradiol.

    Conclusions:

    • Follicular asynchrony and luteal phase deficiency persist as major challenges in ovulation induction for IVF programs.
    • Specific biochemical markers like cyclic adenosine monophosphate offer potential for improving IVF success prediction.
    • Further research is needed to optimize protocols addressing follicular and luteal phase dynamics in assisted reproduction.