Related Experiment Video
Updated: Feb 7, 2026
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
847
Squamous cell carcinoma arising in hypertrophic lichen planus
Caroline Cecile Pauline Haenen1, Aletta Atje Jacoba Buurma2, Roel Erik Genders1,3
1Department of Dermatology, LUMC, Leiden, The Netherlands.
BMJ Case Reports
|July 14, 2018
Summary
Hypertrophic lichen planus (HLP), a chronic skin condition, can rarely transform into squamous cell carcinoma (SCC). Early detection of suspicious changes in long-standing HLP is crucial for timely SCC diagnosis.
Area of Science:
- Dermatology
- Oncology
- Inflammatory Diseases
Background:
- Hypertrophic lichen planus (HLP) is a chronic, T-cell-mediated inflammatory skin condition.
- It typically presents as pruritic, hypertrophic, or verrucous plaques, predominantly on the lower limbs.
Observation:
- A case report details an 87-year-old woman with a 12-year history of HLP on her lower legs.
- One of the long-standing HLP lesions on her leg showed malignant transformation.
Findings:
- The malignant transformation resulted in the development of squamous cell carcinoma (SCC).
- Malignancy arising in cutaneous lichen planus is a rare event, with fewer than 50 cases documented globally.
Implications:
- This case underscores the importance of vigilance for suspicious changes in patients with chronic HLP.
- Prompt identification of potential SCC in HLP lesions is essential for effective patient management and improved outcomes.
Related Concept Videos
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
506
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
506
02:17Ecological Succession
21.6K
Ecological succession is influenced by the processes of facilitation, inhibition, and toleration. Facilitation occurs when early successional species create more favorable ecological conditions for subsequent species, such as enhanced nutrient, water, or light availability. In contrast, inhibition happens when early successional species create unfavorable ecological conditions for potential successive species, such as limiting resource availability. In some cases, later successional species...
21.6K
01:24Biodiversity and Human Values
17.1K
Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.
17.1K
01:07What are Cells?
202.0K
Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
202.0K
01:18Tissues
85.5K
Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
85.5K
02:03What is Cell Signaling?
131.0K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
131.0K