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Updated: Feb 7, 2026

Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics
Published on: August 25, 2022
Fluorescence microscopy applied to intracellular transport by microtubule motors
Divya Pathak1, Shreyasi Thakur, Roop Mallik
1Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Abstract:
Long-distance transport of many organelles inside eukaryotic cells is driven by the dynein and kinesin motors on microtubule filaments. More than 30 years since the discovery of these motors, unanswered questions include motor- organelle selectivity, structural determinants of processivity, collective behaviour of motors and track selection within the complex cytoskeletal architecture, to name a few. Fluorescence microscopy has been invaluable in addressing some of these questions. Here we present a review of some efforts to understand these sub-microscopic machines using fluorescence.
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