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Updated: Feb 7, 2026
09:18
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
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Targeted Approaches for In Situ Gut Microbiome Manipulation
Hui Ling Lee1,2, Haosheng Shen3,4, In Young Hwang5,6
1Department of Biochemistry, Yong Loo Lin School of Medicine, 8 Medical Drive, Singapore 117596, Singapore. bchlhl@nus.edu.sg.
Genes
|July 14, 2018
Summary
Targeted manipulation of the gut microbiome offers therapeutic potential. This review explores strategies for altering gut bacteria populations and metabolic functions to improve host health and restore microbial balance.
Area of Science:
- Microbiology
- Gastroenterology
- Metabolic Engineering
Background:
- The gut microbiome, primarily bacteria, significantly influences host health through secreted metabolites.
- Disruptions in the gut microbiota and metabolome are linked to various diseases and metabolic disorders.
- Growing knowledge of host-microbiome interactions and genetic engineering facilitates microbiome manipulation.
Purpose of the Study:
- To review current strategies for in situ manipulation of the gut microbiome.
- To highlight methods for altering microbial composition and metabolic activity for therapeutic benefit.
Main Methods:
- Review of existing literature on gut microbiome manipulation techniques.
- Categorization of strategies based on precision and mechanism of action.
Main Results:
- Various in situ manipulation strategies exist, targeting microbial populations or metabolic functions.
- Approaches range in their precision and effectiveness for modulating the gut microbiome.
- Successful manipulation can promote health and restore microbial homeostasis.
Conclusions:
- Targeted gut microbiome manipulation is a promising therapeutic avenue.
- Further research into precise and effective manipulation strategies is warranted.
- Modulating the gut microbiome holds potential for treating diseases and improving metabolic health.
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