Related Experiment Video

Updated: Feb 7, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
10:04

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

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New Insights in Anti-Angiogenesis in Multiple Myeloma

Domenico Ribatti1, Angelo Vacca2

  • 1Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari 70124, Italy. domenico.ribatti@uniba.it.

International Journal of Molecular Sciences
|July 14, 2018
PubMed

Insights

Angiogenesis, crucial for multiple myeloma (MM) progression, is targeted by new anti-angiogenic therapies. This review covers agents used in preclinical and clinical MM treatment, offering insights into their efficacy.

Area of Science:

  • Oncology
  • Hematology
  • Molecular Biology

Background:

  • Angiogenesis, the formation of new blood vessels, is a key driver in multiple myeloma (MM) progression.
  • Both plasma cells and the bone marrow microenvironment contribute to the angiogenic process in MM.

Purpose of the Study:

  • To review recent literature on anti-angiogenic therapeutic agents for multiple myeloma (MM).
  • To summarize the application of these agents in both preclinical models and clinical settings.

Main Methods:

  • Literature review of recent studies on anti-angiogenic therapies in multiple myeloma.
  • Analysis of data from preclinical models and clinical trials.

Main Results:

  • Multiple anti-angiogenic agents are under investigation and in clinical use for MM.
  • These agents target the complex angiogenesis pathways within the MM bone marrow microenvironment.

Conclusions:

  • Anti-angiogenic therapies represent a significant therapeutic strategy for managing multiple myeloma.
  • Further research and clinical application of these agents are ongoing for improved MM treatment outcomes.
Keywords:
angiogenesisanti-angiogenesismultiple myelomatumor growth

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