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Related Concept Videos

Types of Fever01:25

Types of Fever

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Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
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Patterns of Fever01:26

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Appendicitis-II: Diagnostic Studies and Management01:29

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Remote Laboratory Management: Respiratory Virus Diagnostics
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Yellow fever in the diagnostics laboratory.

Cristina Domingo1, Rémi N Charrel2,3, Jonas Schmidt-Chanasit4

  • 1Highly Pathogenic Viruses (ZBS 1), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, WHO Collaborating Centre for Emerging Infections and Biological Threats, 13353, Berlin, Germany. Domingo-CarrascoC@rki.de.

Emerging Microbes & Infections
|July 14, 2018
PubMed
Summary

Yellow fever (YF) outbreaks highlight the need for better diagnostics. Current vaccine shortages and diagnostic limitations challenge effective control of this public health threat.

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Area of Science:

  • * Public Health and Tropical Medicine
  • * Infectious Disease Epidemiology

Background:

  • * Yellow fever (YF) persists as a significant public health concern in endemic regions.
  • * Recent urban outbreaks in Angola and the Democratic Republic of Congo (2015-2016) and an ongoing sylvatic outbreak in Brazil (since December 2016) underscore its re-emergence.
  • * Concerns exist regarding the potential for urban transmission cycles in Brazil and subsequent spread to susceptible populations and competent vector areas.

Purpose of the Study:

  • * To analyze the advantages and disadvantages of current Yellow fever diagnostic assays.
  • * To identify barriers hindering timely and efficient laboratory diagnosis of YF.
  • * To emphasize the critical need for novel diagnostic tools to combat YF effectively.

Main Methods:

  • * Review and critical examination of existing Yellow fever diagnostic assays.
  • * Assessment of assay performance, validation status, and practical implementation challenges.
  • * Analysis of serological method limitations and commercial assay availability.

Main Results:

  • * A limited number of validated commercial assays for YF are available.
  • * Existing serological methods present significant shortcomings for widespread diagnostic use.
  • * Implementing accurate YF diagnostics outside specialized reference laboratories is challenging.

Conclusions:

  • * Accurate laboratory confirmation is crucial for efficient Yellow fever outbreak control.
  • * Current diagnostic capabilities are insufficient to meet the challenges posed by YF outbreaks.
  • * Development of new, accessible diagnostic tools is urgently required for effective YF management.