Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal subcapsular islet cell transplantation.

L H Toledo-Pereyra, K O Bandlien, D A Gordon

    The American Surgeon
    |December 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Diagnosis and management of ankylosing spondylitis.

    Canadian family physician Medecin de famille canadien·2011
    Same author

    The Antiseptic Treatment of Phthisis Pulmonalis.

    British medical journal·2010
    Same author

    Nasal Asthma: Its Causes and Treatment.

    British medical journal·2010
    Same author

    A Lecture on Chronic Rhinitis and its Sequelae.

    British medical journal·2010
    Same author

    Intubation of the Larynx.

    British medical journal·2010
    Same author

    Tonsillotomy, with an Analysis of 230 Cases.

    British medical journal·2010
    Same journal

    Learning Surgery's Moral Questions: Mentorship, Reflection, and Professional Formation.

    The American surgeon·2026
    Same journal

    Complete Response of Merkel Cell Carcinoma to Immunotherapy and Single-Fraction Radiotherapy Following Severe COVID-19 Infection: A Case Report and Review of Immune Mechanism.

    The American surgeon·2026
    Same journal

    Perioperative Acute Myocardial Infarction in Non-Cardiac Operations: A National Analysis.

    The American surgeon·2026
    Same journal

    Outcomes of Completion Cholecystectomy: Association With Patient Comorbidity in a National Database.

    The American surgeon·2026
    Same journal

    Building the Conversation: Editorial Stewardship in Contemporary Surgical Publishing.

    The American surgeon·2026
    Same journal

    Musculoskeletal Pain in Surgeons on Operating Days.

    The American surgeon·2026
    See all related articles

    Researchers tested the renal subcapsular region for islet cell allotransplantation (ICTx) and found it a viable alternative site. A simplified, collagenase-free method also proved effective for preparing the pancreatic allograft.

    Area of Science:

    • Transplantation immunology
    • Surgical innovation
    • Endocrinology

    Background:

    • Islet cell allotransplantation (ICTx) is crucial for managing type 1 diabetes.
    • Current ICTx protocols face challenges with graft site and preparation methods.
    • Identifying optimal conditions for ICTx is essential for improving patient outcomes.

    Purpose of the Study:

    • To evaluate the renal subcapsular region (RSC) as a novel site for pancreatic islet allotransplantation.
    • To assess a simplified, non-collagenase method for preparing islet allografts.
    • To compare the efficacy of RSC versus intrasplenic (IS) transplantation sites.

    Main Methods:

    • Pancreatectomized mongrel dogs were divided into five groups.
    • Islet allografts were transplanted into either the RSC or IS site.

    Related Experiment Videos

  • Graft preparation involved both collagenase-free and standard collagenase methods.
  • Graft function and survival were monitored post-transplantation.

    • Main Results:

    • ICTx in the RSC without collagenase resulted in prolonged graft survival (>90 days) in 5/6 animals without immunosuppression.
    • Animals receiving RSC ICTx with minimal immunosuppression showed excellent graft function.
    • Intrasplenic ICTx (both collagenase and non-collagenase methods) resulted in significantly shorter survival times.
    • The collagenase-free preparation method was effective for ICTx.

    Conclusions:

    • The renal subcapsular region is a promising alternative site for islet cell allotransplantation.
    • A simplified, collagenase-free method is suitable for preparing pancreatic allografts for ICTx.
    • These findings support the development of improved ICTx strategies.