Avoiding hot-spots in Microwave-assisted Pd/C catalysed reactions by using the biomass derived solvent
Elena Petricci1, Caterina Risi2, Francesco Ferlin3
1Università degli Studi di Siena, Dipartimento di Biotecnologie, Chimica e Farmacia, Siena, 53100, Italy. elena.petricci@unisi.it.
Abstract:
Herein, we report the use of γ-valerolactone as a new biomass-derived reaction medium for microwave assisted organic synthesis. The interaction of this solvent with microwaves and its heating profile under microwave irradiation has been fully characterized for the first time, demonstrating its stability and the applicability in microwave assisted Pd/C catalysed reactions avoiding the arcing phenomena frequently observed in these conditions. The use of γ-valerolactone demonstrated to be compatible with aliphatic and aromatic amines in the hydrogen transfer Pd/C mediated synthesis of benzimidazoles.
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