Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human placental nucleoside kinase activities.

M C Hurley, I H Fox

    Annals of the New York Academy of Sciences
    |January 1, 1985
    PubMed
    Summary

    Human placental cytosol contains multiple nucleoside kinase enzymes. Deoxyadenosine and deoxyguanosine phosphorylation involve known and uncharacterized enzymes, requiring further study.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correlation of Call Burden and Sleep Deprivation with Physician Burnout, Driving Crashes, and Medical Errors among US Neurointerventionalists.

    AJNR. American journal of neuroradiology·2022
    Same author

    Flow Diversion of Posterior Circulation Aneurysms: Systematic Review of Disaggregated Individual Patient Data.

    AJNR. American journal of neuroradiology·2021
    Same author

    Carotid Stenting without Embolic Protection Increases Major Adverse Events: Analysis of the National Surgical Quality Improvement Program.

    AJNR. American journal of neuroradiology·2021
    Same author

    Refractory Stroke Thrombectomy: Prevalence, Etiology, and Adjunctive Treatment in a North American Cohort.

    AJNR. American journal of neuroradiology·2021
    Same author

    GUide sheath Advancement and aspiRation in the Distal petrocavernous internal carotid artery (GUARD) Technique during Thrombectomy Improves Reperfusion and Clinical Outcomes.

    AJNR. American journal of neuroradiology·2019
    Same author

    Diagnostic Accuracy of High-Resolution Black-Blood MRI in the Evaluation of Intracranial Large-Vessel Arterial Occlusions.

    AJNR. American journal of neuroradiology·2019

    Area of Science:

    • Biochemistry
    • Enzymology
    • Human Physiology

    Background:

    • Nucleoside kinases are crucial enzymes in nucleotide metabolism.
    • Human placental cytosol is a rich source of various enzymatic activities.
    • Understanding these enzymes is vital for comprehending cellular processes.

    Purpose of the Study:

    • To investigate the nucleoside kinase enzyme activities present in normal human placental cytosol.
    • To identify the specific enzymes responsible for deoxyadenosine and deoxyguanosine phosphorylation.

    Main Methods:

    • Analysis of enzyme activities in human placental cytosol.
    • Characterization of phosphorylation pathways for deoxyadenosine and deoxyguanosine.

    Main Results:

    • Human placental cytosol contains a complex mixture of nucleoside kinase enzymes.
    • Deoxyadenosine phosphorylation is mediated by deoxycytidine kinase, adenosine kinase, and two novel activities.
    • Deoxyguanosine phosphorylation is primarily associated with deoxycytidine kinase.

    Conclusions:

    • Human placenta possesses diverse nucleoside kinase activities.
    • Further research is needed to fully characterize the unidentified nucleoside kinase enzymes.
    • These findings contribute to the understanding of nucleotide metabolism in human placenta.

    Related Experiment Videos