High mortality from pyogenic vertebral osteomyelitis: a retrospective cohort study
Martin Brummerstedt1, Marie Bangstrup1, Toke S Barfod1
1Department of Internal Medicine, Zealand University Hospital, Sygehusvej 10, 4000 Roskilde, Denmark.
Spinal Cord Series and Cases
|July 14, 2018
Summary
Pyogenic vertebral osteomyelitis (PVO) is increasing, with high rates of bacteremia and mortality observed in this Danish study. Early diagnosis and identifying microbial causes are crucial for effective treatment strategies.
Area of Science:
- Infectious Diseases
- Orthopedics
- Epidemiology
Background:
- Pyogenic vertebral osteomyelitis (PVO) is a serious spinal infection.
- Understanding its epidemiology and clinical course is vital for patient outcomes.
Purpose of the Study:
- To assess the incidence, diagnostic strategies, treatment, and outcomes of PVO in a non-urban Northern European population.
- To provide insights into PVO management in a specific demographic context.
Main Methods:
- Retrospective cohort study conducted in Region Zealand, Denmark.
- Inclusion criteria: patients admitted with PVO or discitis in 2013.
- Data sourced from central registers and the Danish Civil Registration System.
Main Results:
- Forty-one patients were included, presenting with back pain, fever, elevated C-reactive protein, and bacteremia.
- Fifteen percent in-hospital mortality was reported.
- Median antibiotic treatment duration was 92 days, with heterogeneous regimens.
Conclusions:
- The study supports findings of increasing PVO incidence.
- High rates of bacteremia and mortality were observed, highlighting the severity of PVO.
- Delayed diagnosis and unknown etiology contributed to prolonged and varied treatment.
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