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Therapeutic neovascularization promoted by injectable hydrogels.
Amrita Pal1, Brent L Vernon1, Mehdi Nikkhah1
1School of Biological and Health Systems Engineering, Arizona State University, Arizona 85281, USA.
Bioactive Materials
|July 14, 2018
Summary
Injectable hydrogels offer a promising solution for controlled delivery of angiogenic factors and stem cells to repair ischemic tissues. These advanced biomaterials enhance neovascularization for effective tissue regeneration and wound healing.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Therapeutic neovascularization aims to restore blood supply to ischemic tissues.
- Controlled release of angiogenic factors is crucial for effective tissue repair, as bolus injections yield poor outcomes.
- Injectable hydrogels provide a promising platform for localized delivery of therapeutic agents and cells.
Purpose of the Study:
- To review the current advancements in injectable hydrogels for therapeutic neovascularization.
- To discuss the application of these hydrogels in ischemic tissue repair and wound healing.
- To explore hydrogels promoting neovascularization through self-healing mechanisms.
Main Methods:
- Comprehensive review of in vitro and in vivo studies on injectable hydrogels.
- Analysis of natural, synthetic, and hybrid biomaterial-based hydrogels.
- Evaluation of hydrogel functionalities in promoting tissue repair and neovascularization.
Main Results:
- Injectable hydrogels enable controlled delivery of angiogenic factors and stem cells for in situ tissue repair.
- Engineered hydrogels demonstrate efficacy in promoting neovascularization and healing in various models.
- Certain injectable hydrogels exhibit self-healing properties, driving neovascularization independently of exogenous angiogenic factors.
Conclusions:
- Injectable hydrogels represent a significant breakthrough in regenerative medicine for treating ischemic conditions.
- The development of advanced hydrogel formulations is key to improving therapeutic neovascularization strategies.
- Future research should focus on harnessing self-healing hydrogels for enhanced neovascularization and tissue regeneration.
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