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Potential strain-dependent mechanisms defining matrix alignment in healing tendons.

William J Richardson1,2, Brian Kegerreis3, Stavros Thomopoulos4,5

  • 1Department of Bioengineering, Clemson University, Clemson, SC, USA.

Biomechanics and Modeling in Mechanobiology
|July 14, 2018
PubMed
Summary

Healing tendons show complex collagen changes. Mechanical loading influences collagen content and alignment differently, with two potential mechanisms identified: strain-induced damage/deposition or strain-dependent degradation.

Keywords:
CollagenComputational modelMechanobiologyTendonWound healing

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Area of Science:

  • Biomedical Engineering
  • Tissue Engineering
  • Computational Biology

Background:

  • Tendon mechanical function relies on collagen structure, influenced by healing loads.
  • Conflicting experimental data show collagen content increases with load, but alignment peaks at intermediate loads.

Purpose of the Study:

  • To explore collagen remodeling mechanisms causing divergent content and alignment during tendon healing.
  • To simulate strain-dependent cell and collagen interactions.

Main Methods:

  • Adapted an established agent-based model of collagen remodeling.
  • Simulated various strain-dependent cell and collagen interactions.

Main Results:

  • Identified two mechanisms for divergent collagen content and alignment:
  • 1. Strain-induced collagen fiber damage with increased deposition at higher strains.
  • 2. Strain-dependent enzymatic degradation rates.

Conclusions:

  • Model predictions offer insights into tendon healing.
  • Suggests future experiments to isolate specific collagen remodeling mechanisms.