Related Experiment Video
Updated: Feb 7, 2026
07:12
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
4.9K
Solid Cell Nests Within a Parathyroid Gland-Report of an Exceptional Case
C Christofer Juhlin1,2, Inga-Lena Nilsson3,4, Anders Höög5,6
1Department of Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden. christofer.juhlin@ki.se.
Endocrine Pathology
|July 14, 2018
Summary
Solid cell nests (SCNs), remnants of the ultimobranchial body, are typically found in the thyroid. This report details the first documented instance of SCNs discovered within a parathyroid gland, suggesting potential developmental anomalies.
Area of Science:
- Histopathology
- Embryology
- Endocrinology
Background:
- The ultimobranchial body (UBB) originates from the fourth branchial pouch and forms calcitonin-secreting C cells within the thyroid.
- Remnants of the UBB, known as solid cell nests (SCNs), are commonly found in thyroid tissue.
- The superior parathyroid glands share a close embryological origin with the UBB.
Observation:
- A patient with papillary thyroid carcinoma unexpectedly had a parathyroid gland removed during surgery.
- Histological examination revealed solid nests of epithelial cells within this parathyroid gland.
- These cells were positive for p40, p63, and GATA3, but negative for parathyroid hormone (PTH).
Findings:
- The histological features confirmed the presence of a solid cell nest (SCN) within the parathyroid gland.
- This represents the first reported case of SCNs found intraparathyroideally.
- The cells' immunophenotype was consistent with SCNs, distinct from parathyroid tissue.
Implications:
- This unusual finding suggests a potential embryological aberrancy during development.
- The close anatomical relationship between the UBB and superior parathyroid glands may facilitate such inclusions.
- Further investigation into developmental pathways may clarify the origins of intraparathyroidal SCNs.
More Related Videos
Related Concept Videos
00:59The Parathyroid Glands
5.3K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
5.3K
02:55Exceptions to the Octet Rule
37.8K
Many covalent molecules have central atoms that do not have eight electrons in their Lewis structures. These molecules fall into three categories:
37.8K
02:22Structures of Solids
17.9K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
17.9K
02:37Metallic Solids
20.8K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.8K
02:18Network Covalent Solids
16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
02:54Molecular and Ionic Solids
20.2K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.2K