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Updated: Feb 7, 2026

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Plastic Scintillator-Based Microfluidic Devices for Miniaturized Detection of Positron Emission Tomography
Mark D Tarn1,2,3, Nuray Yavuzkanat Kızılyer4,5, Mohammad M N Esfahani1,6
1Positron Emission Tomography Research Centre, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
Abstract:
A miniaturized radio-HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron-emitting radionuclide, [18 F]fluoride. This cost-effective, small footprint analytical tool is ideal for incorporation into integrated quality control systems for the testing of positron emission tomography (PET) radiopharmaceuticals to good manufacturing practice (GMP) standards.
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