DNA topoisomerases as targets for cancer therapy

UP element-dependent transcription at the Escherichia coli rrnB P1 promoter: positional requirements and role of the RNA polymerase alpha subunit linker.

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Dissociation of cytotoxicity and DNA cleavage activity induced by topoisomerase II-reactive intercalating agents in hamster-human somatic cell hybrids.

Cancer chemotherapy and pharmacology·1992

Resistance to inhibitors of DNA topoisomerases.

Cancer treatment and research·1991

Possible role for p34cdc2 kinase in etoposide-induced cell death of Chinese hamster ovary cells.

Cancer research·1990

Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells.

Cancer research·1990

Dual GPX4/PARP inhibitor YHD-26 exerts potent antitumor activity against triple-negative breast cancer via ferroptosis and DNA damage synergy.

Biochemical pharmacology·2026

Synergistic breakthrough of Melissa officinalis L. Essential oil-loaded nanostructured lipid carrier for combating colistin resistance of MCR-1 positive Escherichia coli.

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KDM1A/HDAC2-driven epigenetic dysregulation maintains a drug-resistant, relapse-initiating glioblastoma cell niche at the peri-tumoral margin.

Biochemical pharmacology·2026

Chitosan-selenium nanoparticles prevent retinal ganglion cell apoptosis in glaucoma via activation of the PI3K/Akt/Nrf2 antioxidant axis.

Biochemical pharmacology·2026

Trimethylamine N-oxide drives cardiac hypertrophy through H3K27ac-mediated enhancer activation of ketohexokinase.

Biochemical pharmacology·2026

CRISPR screens for the discovery of novel ferroptosis targets: progress and perspectives.

Biochemical pharmacology·2026

Multi-Omics Genome-Wide to Explore the Formation and Development Targets for Intracranial Aneurysms.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026

Triggering SORL1 Expression Restricts ccRCC Progression by Inducing Ubiquitination-Mediated c-Myc Degradation.

Cancer science·2026

FIN56-induced ferroptosis suppresses the development of endometriosis by augmenting mitochondrial ROS and lipid peroxidation via the ACACA/ARID5A/NOX4 axis.

Chinese medical journal·2026

Regulatory and Quality Considerations of Antibody-drug Conjugates.

AAPS PharmSciTech·2026

HDAC inhibition via suberoylanilide hydroxamic acid ameliorates doxorubicin-induced cardiotoxicity.

Nature communications·2026

Dual HBV cccDNA-linked HiBiT reporter hepatocyte models for screening of candidate cccDNA modulators.

Virulence·2026

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DNA topoisomerases as targets for cancer therapy

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UP element-dependent transcription at the Escherichia coli rrnB P1 promoter: positional requirements and role of the RNA polymerase alpha subunit linker.

Evaluation of an omental pedicle extension technique in the dog.

Dissociation of cytotoxicity and DNA cleavage activity induced by topoisomerase II-reactive intercalating agents in hamster-human somatic cell hybrids.

Resistance to inhibitors of DNA topoisomerases.

Possible role for p34cdc2 kinase in etoposide-induced cell death of Chinese hamster ovary cells.

Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells.

Dual GPX4/PARP inhibitor YHD-26 exerts potent antitumor activity against triple-negative breast cancer via ferroptosis and DNA damage synergy.

Synergistic breakthrough of Melissa officinalis L. Essential oil-loaded nanostructured lipid carrier for combating colistin resistance of MCR-1 positive Escherichia coli.

KDM1A/HDAC2-driven epigenetic dysregulation maintains a drug-resistant, relapse-initiating glioblastoma cell niche at the peri-tumoral margin.

Chitosan-selenium nanoparticles prevent retinal ganglion cell apoptosis in glaucoma via activation of the PI3K/Akt/Nrf2 antioxidant axis.

Trimethylamine N-oxide drives cardiac hypertrophy through H3K27ac-mediated enhancer activation of ketohexokinase.

CRISPR screens for the discovery of novel ferroptosis targets: progress and perspectives.

Multi-Omics Genome-Wide to Explore the Formation and Development Targets for Intracranial Aneurysms.

Triggering SORL1 Expression Restricts ccRCC Progression by Inducing Ubiquitination-Mediated c-Myc Degradation.

FIN56-induced ferroptosis suppresses the development of endometriosis by augmenting mitochondrial ROS and lipid peroxidation via the ACACA/ARID5A/NOX4 axis.

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