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Proteomic profiles by multiplex microsphere suspension array
Viswanathan V Krishnan1, Senthamil R Selvan2, Nishanth Parameswaran2
1Department of Chemistry, California State University, Fresno, CA 93750, United States; Department of Medical Pathology and Laboratory Medicine, University of California School of Medicine, Sacramento, CA 95817, United States.
Multiplexed microsphere suspension array technology enhances disease biomarker discovery for clinical diagnostics. This advanced proteomic approach offers precise measurements for personalized medicine applications.
Area of Science:
- Biotechnology and Proteomics
- Clinical Diagnostics and Biomarker Discovery
Background:
- High-throughput proteomic advancements are crucial for identifying novel disease biomarkers.
- Multiplexed microsphere suspension array technology is increasingly adopted in clinical settings for diagnostics and prognostics.
Purpose of the Study:
- To provide a foundational understanding of multiplexed microsphere suspension array technology.
- To highlight improvements in the technology, data analysis, and its applications in translational and clinical research.
- To emphasize the implications for personalized and precision medicine.
Main Methods:
- Utilizes multiplex microsphere immunoassays for quantitative measurement of specific molecular markers.
- Focuses on selected sets of markers including cytokines, chemokines, pathway signaling molecules, and disease-specific targets.
Main Results:
- Demonstrates the capability of multiplex microsphere immunoassays to detect markers relevant to metabolic disorders, cancer, and infectious diseases.
- Highlights the advantages over conventional proteomic approaches in terms of specificity and quantitative measurement of selected markers.
Conclusions:
- Multiplexed microsphere suspension array technology represents a significant advancement in disease biomarker discovery.
- The technology supports precise detection of molecular markers, paving the way for improved clinical diagnostics and personalized medicine strategies.
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