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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Colloids and Suspensions01:17

Colloids and Suspensions

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Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...
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Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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Taping Over Different Ground Profiles01:12

Taping Over Different Ground Profiles

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Taping over varying ground profiles requires careful adaptation to achieve accurate measurements. On smooth, level ground with minimal vegetation, the tape can rest directly on the ground. Here, the taping team, typically consisting of a head and a rear tapeman, coordinates their positions with clear communication. The rear tapeman holds the tape at the starting point and guides the head tapeman toward a range pole placed beyond the endpoint, using hand or voice signals to ensure alignment.On...
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Profile Leveling and Cross Sections01:26

Profile Leveling and Cross Sections

1.7K
Profile leveling and cross-sections are surveying methods used to determine and document terrain elevations for infrastructure projects such as highways, railroads, canals, and pipelines. These methods provide data for earthwork planning and alignment of proposed routes.  Profile leveling involves measuring elevations along a fixed line to create a vertical terrain profile. A surveyor sets up a leveling instrument at the benchmark (BM) and records a backsight (BS) to determine the...
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Drug Dissolution: Requirements and Profile Comparison01:14

Drug Dissolution: Requirements and Profile Comparison

282
The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...
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Author Spotlight: Advancing Antiviral Strategies Through Novel Immunocapture and Mass Spectrometry Techniques
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Proteomic profiles by multiplex microsphere suspension array.

Viswanathan V Krishnan1, Senthamil R Selvan2, Nishanth Parameswaran2

  • 1Department of Chemistry, California State University, Fresno, CA 93750, United States; Department of Medical Pathology and Laboratory Medicine, University of California School of Medicine, Sacramento, CA 95817, United States.

Journal of Immunological Methods
|July 14, 2018
PubMed
Summary
This summary is machine-generated.

Multiplexed microsphere suspension array technology enhances disease biomarker discovery for clinical diagnostics. This advanced proteomic approach offers precise measurements for personalized medicine applications.

Keywords:
BiomarkersImmunoassayMicrobead ArrayMultiplex AssayProteomics

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Area of Science:

  • Biotechnology and Proteomics
  • Clinical Diagnostics and Biomarker Discovery

Background:

  • High-throughput proteomic advancements are crucial for identifying novel disease biomarkers.
  • Multiplexed microsphere suspension array technology is increasingly adopted in clinical settings for diagnostics and prognostics.

Purpose of the Study:

  • To provide a foundational understanding of multiplexed microsphere suspension array technology.
  • To highlight improvements in the technology, data analysis, and its applications in translational and clinical research.
  • To emphasize the implications for personalized and precision medicine.

Main Methods:

  • Utilizes multiplex microsphere immunoassays for quantitative measurement of specific molecular markers.
  • Focuses on selected sets of markers including cytokines, chemokines, pathway signaling molecules, and disease-specific targets.

Main Results:

  • Demonstrates the capability of multiplex microsphere immunoassays to detect markers relevant to metabolic disorders, cancer, and infectious diseases.
  • Highlights the advantages over conventional proteomic approaches in terms of specificity and quantitative measurement of selected markers.

Conclusions:

  • Multiplexed microsphere suspension array technology represents a significant advancement in disease biomarker discovery.
  • The technology supports precise detection of molecular markers, paving the way for improved clinical diagnostics and personalized medicine strategies.