[Research Progress in Virus Infection Altering Cellular Glucose Metabolism]

Area of Science:

• Virology
• Cellular Metabolism
• Molecular Biology

Background:

• Viruses rely on host cellular metabolism for proliferation.
• Glucose metabolism is a critical cellular process significantly altered during viral infections.
• Understanding these metabolic alterations is key to comprehending viral pathogenesis.

Purpose of the Study:

• To review the mechanisms by which viruses alter host cellular glucose metabolism.
• To explore the impact of viral infections on glucose transport and related gene expression.
• To provide a reference for studying virus-induced changes in cellular glucose metabolism.

Main Methods:

• Literature review of studies on viral hijacking of cellular metabolism.
• Analysis of mechanisms affecting glucose transport.
• Examination of alterations in genes related to glycolysis, pentose phosphate pathway, and gluconeogenesis.

Main Results:

• Viruses significantly alter glucose transport and uptake in host cells.
• Viral infections dramatically change the expression of key glucose metabolism-related genes.
• Islet cells and insulin receptor signaling are affected by certain viral infections.

Conclusions:

• Viral infections profoundly reprogram host cellular glucose metabolism to favor viral replication.
• Altered glucose metabolism impacts host cell function and provides targets for antiviral strategies.
• This review consolidates current knowledge on virus-host metabolic interactions.