Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

4.9K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
4.9K
Freezing Point Depression and Boiling Point Elevation03:12

Freezing Point Depression and Boiling Point Elevation

40.3K
Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
40.3K
Elevation of Intermediate Points on Vertical Curves01:20

Elevation of Intermediate Points on Vertical Curves

308
Vertical curves are essential in roadway design because they provide smooth transitions between varying roadway grades. Designing vertical curves involves calculating intermediate elevations and identifying the curve's highest or lowest point, which is essential for optimal roadway performance.Intermediate elevations on a vertical curve are determined using the tangent offset method. This method considers the initial elevation at the start of the curve, the grades, and the curve's geometry. The...
308
Setting Time of Cement01:12

Setting Time of Cement

700
The setting time of cement refers to the process of cement paste transitioning from a plastic state to a solid state. This process is crucial in construction as it dictates the timeframe for concrete placement, compaction, and finishing. The onset of this solidification is termed the initial set, indicating when the paste becomes unworkable. The final set is when the paste has solidified completely, and further handling or manipulation can no longer affect its shape. The cement strength is...
700
Node Analysis for AC Circuits01:14

Node Analysis for AC Circuits

681
Consider an angioplasty system featuring a catheter equipped with a turbine, a critical tool for removing plaque deposits from coronary arteries. This intricate medical device operates using a circuit model reminiscent of a dual-node RLC circuit powered by a current-controlled voltage source.
To unravel the complexities of this system, nodal analysis is employed, a powerful technique founded on Kirchhoff's current law (KCL), which remains valid for phasors. AC circuits can effectively be...
681
Specialized Care Centers and Settings-II01:30

Specialized Care Centers and Settings-II

1.3K
Rural Health Centers
Rural health centers are specialized care facilities in remote locations with very few medical personnel. The primary care providers who run the centers are mostly Registered Nurse Practitioners. Here, emergency treatment is provided to critically ill or injured patients before they are transferred to the closest hospital. Fortunately, due to advancement in technology, many rural healthcare facilities and professionals have easy access to diagnostic and treatment...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Treatment Intensity on Quality of Life in Patients With Metastatic Testicular Cancer.

Andrology·2026
Same author

MRI Quality and Reader Experience in Organized Prostate Cancer Screening: Insights from the PROBASE Trial.

European urology oncology·2026
Same author

From Evidence to Implementation: How Should We Screen for Prostate Cancer in the Modern Era?: Editorial to: Nguyen DD, Tadayon B, Lin L, et al. Effect of Prostate Cancer Screening with Prostate-specific Antigen Testing on Long-term Prostate Cancer-specific Mortality: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Eur Urol. 2026. In press. https://doi.org/10.1016/j.eururo.2026.04.005.

European urology·2026
Same author

[Reducing overdiagnosis-how to do I correctly assess the indication for prostate biopsy?]

Urologie (Heidelberg, Germany)·2026
Same author

Smart Screening in Prostate Cancer: What We Have Learned So Far from PROBASE.

European urology focus·2026
Same author

PRIMA: randomized prospective multicenter non-inferiority study for primary diagnosis of clinically significant PRostate cancer by PSA and MR IMAging-study protocol for a randomized diagnostic accuracy trial.

Trials·2026

Related Experiment Video

Updated: Feb 7, 2026

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice
16:48

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

Published on: August 23, 2007

47.8K

Retroperitoneal lymph node dissection in the setting of elevated markers.

Jale Lakes1, Achim Lusch1, Alessandro Nini1,2

  • 1Department of Urology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.

Current Opinion in Urology
|July 14, 2018
PubMed
Summary
This summary is machine-generated.

Surgical resection can be a curative salvage option for select patients with metastatic germ cell tumors and elevated markers after chemotherapy. Identifying suitable candidates preoperatively improves long-term outcomes.

More Related Videos

Intravital Microscopy of the Inguinal Lymph Node
07:34

Intravital Microscopy of the Inguinal Lymph Node

Published on: April 4, 2011

21.0K
Murine Superficial Lymph Node Surgery
04:36

Murine Superficial Lymph Node Surgery

Published on: May 21, 2012

43.7K

Related Experiment Videos

Last Updated: Feb 7, 2026

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice
16:48

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

Published on: August 23, 2007

47.8K
Intravital Microscopy of the Inguinal Lymph Node
07:34

Intravital Microscopy of the Inguinal Lymph Node

Published on: April 4, 2011

21.0K
Murine Superficial Lymph Node Surgery
04:36

Murine Superficial Lymph Node Surgery

Published on: May 21, 2012

43.7K

Area of Science:

  • Oncology
  • Surgical Oncology
  • Germ Cell Tumors

Background:

  • Management of residual masses in metastatic germ cell tumors (GCT) with elevated markers post-chemotherapy is challenging.
  • Salvage chemotherapy offers limited benefit in chemotherapy-resistant GCT.
  • Surgical resection has shown efficacy in select GCT patients.

Purpose of the Study:

  • To evaluate pre- and postoperative factors for identifying suitable candidates for surgical resection.
  • To determine predictors of favorable outcomes in GCT patients undergoing tumor resection.

Main Methods:

  • Retrospective analysis of pre- and postoperative factors in patients with metastatic GCT.
  • Evaluation of International Germ Cell Cancer Collaborative group prognostic factors.
  • Assessment of tumor markers, lymph node involvement, and resected tissue characteristics.

Main Results:

  • Favorable preoperative factors include good prognosis, high alpha-fetoprotein (not beta-HCG), stable/decreasing markers, and teratomatous elements.
  • Retroperitoneal/mediastinal lymph nodes predict good outcomes due to resectability.
  • Teratoma/necrosis in resected tissue and postoperative marker normalization indicate favorable prognosis.

Conclusions:

  • Radical surgery is a potentially curative salvage option for advanced, chemorefractory GCT with elevated markers.
  • Complete resection is crucial for achieving favorable outcomes.
  • Surgical consideration in selected patients can avoid ineffective salvage chemotherapy.