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Zika Virus Specific Diagnostic Epitope Discovery
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Minimum InDel pattern analysis of the Zika virus.

Hyeji Lee1, Mai Phuong Nguyen1, Yunhee Choi1

  • 1Department of Microbiology, Daegu Catholic University School of Medicine, Daegu, 42472, Republic of Korea.

BMC Genomics
|July 15, 2018
PubMed
Summary

Zika virus (ZIKV) typing is now possible using insertion/deletion patterns in its E protein. This method distinguishes ZIKV types I and II, aiding in rapid detection and understanding virus evolution.

Keywords:
Envelope proteinMinimum InDelPolyproteinVirus typingZika virus

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Area of Science:

  • Virology
  • Molecular Evolution
  • Genomics

Background:

  • Zika virus (ZIKV) poses risks, causing microcephaly and congenital abnormalities.
  • Understanding ZIKV evolution and distinct types is crucial for public health.
  • Previous studies offered insights but lacked definitive type determination.

Purpose of the Study:

  • To determine the distinct types of Zika virus (ZIKV).
  • To identify molecular markers for ZIKV type differentiation.
  • To analyze ZIKV evolution using sequence data.

Main Methods:

  • Analysis of insertions and deletions (InDels) in 212 ZIKV polyproteins.
  • Utilized minimum InDel (minInDel) patterns and Spearman correlation tests.
  • Employed likelihood estimation to correct evolutionary distances.

Main Results:

  • A unique minInDel character in the E protein distinguished ZIKV types I and II.
  • The minInDel-corrected tree topology clearly separated ZIKV types.
  • Estimated African and Asian lineages of ZIKV type II emerged approximately 270 years ago.

Conclusions:

  • MinInDel pattern analysis enables rapid detection and determination of ZIKV types.
  • The E protein's minInDel is a targetable marker for ZIKV typing.
  • This method enhances understanding of ZIKV's evolutionary history.